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Your Guide to NSI-189: Benefits, Dosage, and More

Looking to optimize your health or performance with NSI-189? This guide breaks down everything you need to know about this popular experimental neurogenic compound, from its benefits and dosage to the latest research and biohacker insights.

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What is NSI-189?

NSI-189 is an investigational synthetic neurogenic compound developed by Neuralstem, Inc. It has been studied for its potential effects on mood disorders and cognitive function, particularly its ability to promote neurogenesis.

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Key Potential Benefits & Uses

Based on research and biohacker experiences, NSI-189 is often used for:

• Mood Improvement: May help alleviate symptoms associated with depression and improve overall mood.
• Cognitive Enhancement: Users report potential improvements in memory, focus, and clarity.
• Neurogenesis: Preclinical studies suggest it can promote the growth of new neurons, particularly in the hippocampus.
• Mechanism: Works by potentially stimulating neurogenesis (the creation of new brain cells) and synaptic plasticity in the hippocampus.

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Scientific Evidence: What Does the Research Say?

• Brief summary of key studies or level of evidence: Clinical trials have investigated NSI-189 for major depressive disorder, showing some positive results, though further research is needed. Preclinical studies in animal models have demonstrated its neurogenic effects.
• Strength of Evidence: Emerging

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How to Take NSI-189

• Common Forms: Powder, Capsules
• Typical Dosage: Research dosages have ranged from 20mg to 80mg per day, often split into two doses. Consultation with a healthcare professional is advised, especially given its investigational status.
• Timing: Often taken once or twice daily, with or without food.

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Synergies & Stacking

• NSI-189 is often stacked with other cognitive enhancers, adaptogens, or mood support supplements like Lion's Mane, Bacopa Monnieri, or Rhodiola Rosea.

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Potential Side Effects & Precautions

Like any supplement, NSI-189 may cause side effects, though they are typically mild or dose-dependent. These can include:

• Headache: Some users report transient headaches, especially at higher doses.
• Fatigue: A feeling of tiredness has been reported by some individuals.
• Changes in Mood: While intended to improve mood, some users report paradoxical effects or irritability.
• Precautions: NSI-189 is an investigational drug and not approved for human use outside of clinical trials. Long-term safety data is limited. Do not use if pregnant, breastfeeding, or if you have a history of neurological or psychiatric conditions without strict medical supervision.

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Choosing the Right Form & Quality

• Quality Tips: Given its status as a research chemical, sourcing from reputable vendors is crucial. Look for vendors who can provide evidence of purity, such as third-party testing, though comprehensive testing may be difficult to verify.

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Biohacker Insights & Community Experiences

• Common Experiences: Many users report a gradual improvement in mood and emotional resilience over several weeks of use. Some also note enhanced cognitive function, including improved memory recall and mental clarity.

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Frequently Asked Questions (FAQs)

• Is NSI-189 approved for medical use?
  • Answer: No, NSI-189 is an investigational compound and is not approved by regulatory bodies like the FDA for medical treatment.
• How long does it take to see effects from NSI-189?
  • Answer: Anecdotal reports suggest effects on mood and cognition may become noticeable after several weeks or months of consistent use, aligning with potential neurogenic processes.

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Disclaimer

This guide is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any new supplement, especially if you have underlying health conditions or are taking medications.