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Your Guide to Luteolin: Benefits, Dosage, and More

Looking to optimize your health or performance with Luteolin? This guide breaks down everything you need to know about this popular flavonoid, from its benefits and dosage to the latest research and biohacker insights.

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What is Luteolin?

Luteolin is a naturally occurring flavonoid found in many plants, including celery, parsley, broccoli, and citrus fruits. It is recognized for its potent antioxidant and anti-inflammatory properties.

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Key Potential Benefits & Uses

Based on research and biohacker experiences, Luteolin is often used for:

• Anti-inflammatory Support: Helps modulate the body's inflammatory response by inhibiting pro-inflammatory pathways.
• Antioxidant Protection: Scavenges free radicals, reducing oxidative stress and cellular damage.
• Neuroprotection: Shows potential in protecting brain cells and supporting cognitive function, possibly by reducing neuroinflammation.
• Allergy & Immune Support: May help stabilize mast cells, potentially reducing the release of histamine and other inflammatory mediators involved in allergic reactions.
• Mechanism: Primarily works by inhibiting key enzymes and transcription factors involved in inflammation (like COX-2, LOX, NF-κB) and acting as a direct free radical scavenger.

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Scientific Evidence: What Does the Research Say?

• Moderate evidence supports Luteolin's antioxidant and anti-inflammatory effects, primarily from in vitro and animal studies. Human research, often using Luteolin in combination with other compounds or focusing on specific conditions, is emerging.
• Strength of Evidence: Moderate

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How to Take Luteolin

• Common Forms: Capsules, Powder.
• Typical Dosage: A general range is 50-200 mg per day, though some studies use higher doses. Always consult a healthcare professional for personalized advice.
• Timing: Often suggested to be taken with meals for better absorption.
• Bioavailability Tips: Bioavailability Tips: Luteolin has relatively low oral bioavailability; taking it with a source of healthy fat or using formulations designed for enhanced absorption (e.g., phytosomes) may be beneficial.

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Synergies & Stacking

• Luteolin is often stacked with Quercetin (another flavonoid with similar properties) or Piperine (to potentially enhance absorption).

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Potential Side Effects & Precautions

Like any supplement, Luteolin may cause side effects, though they are typically mild. These can include:

• Gastrointestinal Upset: Mild stomach discomfort or nausea, especially at higher doses.
• Precautions: Limited safety data is available for pregnant or breastfeeding women and children. Individuals on blood-thinning medications should consult a doctor due to theoretical interactions related to COX inhibition.

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Choosing the Right Form & Quality

• Quality Tips: Look for products that provide standardized extracts of Luteolin. Opt for brands that conduct third-party testing for purity and potency.

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Biohacker Insights & Community Experiences

• Common Experiences: Some users report reduced allergy symptoms, less brain fog, and general feelings of reduced inflammation. It's often included in stacks aimed at longevity or cognitive health.

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Frequently Asked Questions (FAQs)

• What foods are high in Luteolin?
  • Answer: Foods like celery, parsley, oregano, thyme, rosemary, broccoli, carrots, peppers, and citrus fruits are good dietary sources.
• Can Luteolin help with seasonal allergies?
  • Answer: Due to its potential mast cell stabilizing and anti-inflammatory effects, some individuals use it for allergy support, though research is still developing in this specific application.

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Disclaimer

This guide is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any new supplement, especially if you have underlying health conditions or are taking medications.