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Track your Biohacking Protocols & Supplements with the Biohackr IOS app

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Your Guide to MOTS-c: Benefits, Dosage, and More

Looking to optimize your health or performance with MOTS-c? This guide breaks down everything you need to know about this popular peptide, from its benefits and dosage to the latest research and biohacker insights.

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What is MOTS-c?

MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial genome. It plays a crucial role in regulating metabolic homeostasis and cellular energy.

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Key Potential Benefits & Uses

Based on research and biohacker experiences, MOTS-c is often used for:

• Metabolic Health: May help regulate glucose and lipid metabolism, potentially improving insulin sensitivity.
• Exercise Performance: Research suggests it could enhance exercise capacity and endurance.
• Longevity & Aging: Linked to pathways associated with healthy aging and cellular resilience.
• Cellular Energy: Supports mitochondrial function, the powerhouses of the cell.
• Mechanism: Works by influencing mitochondrial function and interacting with nuclear genes involved in metabolism.

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Scientific Evidence: What Does the Research Say?

• Emerging research primarily from animal and in vitro studies indicates promising effects on metabolism, exercise, and aging, with limited but growing human data.
• Strength of Evidence: Emerging

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How to Take MOTS-c

• Common Forms: Injectable (Subcutaneous or Intramuscular).
• Typical Dosage: Varies widely depending on individual goals and professional guidance, often ranging from 5-10mg per week, sometimes split into multiple doses. Always consult a healthcare professional.
• Timing: Often administered daily or several times per week, sometimes as part of a cyclical regimen.
• Bioavailability Tips: As a peptide, oral administration is ineffective due to digestion. Injection is required for systemic effects.

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Synergies & Stacking

• MOTS-c is often stacked with exercise itself to potentially amplify metabolic and performance benefits, and sometimes with other compounds targeting metabolic health or longevity pathways (e.g., NAD+ precursors).
• Avoid Combining With: Individuals with specific metabolic disorders or those taking medications affecting glucose/lipid metabolism should exercise caution and consult a healthcare professional.

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Potential Side Effects & Precautions

Like any supplement, MOTS-c may cause side effects, though they are typically dose-dependent. These can include:

• Injection Site Reactions: Redness, swelling, or discomfort at the injection site.
• [Precautions]: Requires sterile administration via injection, which carries inherent risks. Should only be used under the supervision of a qualified healthcare professional due to its nature as a peptide and limited human data.

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Choosing the Right Form & Quality

• Quality Tips: Look for sourcing from reputable peptide suppliers and request third-party testing (e.g., HPLC/MS) to verify purity and identity. Proper storage (refrigeration) is critical.

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Biohacker Insights & Community Experiences

• Common Experiences: Many users report improvements in energy levels, body composition (especially when combined with exercise), and recovery.
• Pro Tip: Ensure proper reconstitution and sterile injection techniques if self-administering under medical guidance.

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Frequently Asked Questions (FAQs)

• How is MOTS-c administered?
  • Answer: MOTS-c is typically administered via subcutaneous or intramuscular injection.
• Is MOTS-c legal?
  • Answer: The legality of MOTS-c varies by region and intended use. It is often available for research purposes but may not be approved for human therapeutic use in all areas.

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Disclaimer

This guide is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any new supplement, especially if you have underlying health conditions or are taking medications.