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Your Guide to Celastrol: Benefits, Dosage, and More

Looking to optimize your health or performance with Celastrol? This guide breaks down everything you need to know about this potent natural compound, from its benefits and dosage to the latest research and biohacker insights.

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What is Celastrol?

Celastrol is a triterpenoid compound isolated from the roots of the Tripterygium wilfordii (Thunder God Vine) plant. It is known for its significant anti-inflammatory, antioxidant, and potential metabolic effects.

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Key Potential Benefits & Uses

Based on research and biohacker experiences, Celastrol is often used for:

• Anti-inflammatory Effects: Potent inhibitor of inflammatory pathways, including NF-κB.
• Antioxidant Properties: Helps reduce oxidative stress in the body.
• Potential Anti-Obesity Effects: Research suggests it may improve leptin sensitivity and influence energy metabolism.
• Potential Anti-Cancer Effects: Studied for its ability to inhibit growth and induce cell death in various cancer cell lines.
• Mechanism: Primarily acts through potent anti-inflammatory and antioxidant pathways, and is being researched for its effects on leptin signaling.

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Scientific Evidence: What Does the Research Say?

• Brief summary of key studies or level of evidence: Research, predominantly in in vitro and animal models, supports Celastrol's potent anti-inflammatory, antioxidant, and metabolic effects. Human clinical trials are limited but ongoing, particularly in areas like obesity and inflammatory diseases.
• Strength of Evidence: Emerging (for human application, based on preclinical data).

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How to Take Celastrol

• Common Forms: Typically available as a purified extract in capsule or powder form.
• Typical Dosage: There is no widely established human dosage for Celastrol due to its potency and potential toxicity. Research dosages are often very low (microgram to low milligram range). Any use should be under strict medical supervision.
• Timing: Not well-established; often suggested to take with food due to its lipophilic nature.
• Bioavailability Tips: May be enhanced when taken with dietary fats; liposomal formulations are being explored.

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Synergies & Stacking

• Celastrol is not commonly stacked with other supplements in typical biohacking contexts due to its potency and the lack of established safety protocols. Research often investigates its effects alone or in specific drug combinations.
• Avoid Combining With: Exercise caution when combining with immunosuppressants or other potent anti-inflammatory medications unless under medical guidance.

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Potential Side Effects & Precautions

Like any supplement, Celastrol may cause side effects, though they are typically dose-dependent and can be serious due to the source plant's toxicity. These can include:

• Gastrointestinal Issues: Nausea, vomiting, diarrhea.
• Liver Toxicity: Potential for liver enzyme elevation or damage, especially with improper sourcing or dosage.
• Reproductive Issues: Historically linked to Tripterygium wilfordii extracts; potential concerns remain with purified Celastrol.
• Precautions: Celastrol is derived from a highly toxic plant (Tripterygium wilfordii). Purified extracts require extreme caution. Do not use without consulting a qualified healthcare professional due to potential severe side effects and lack of established human safety data. Not recommended for individuals with liver or kidney disease, or those who are pregnant or breastfeeding.

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Choosing the Right Form & Quality

• Quality Tips: Look for highly purified Celastrol extracts with third-party testing to verify purity and ensure the absence of other toxic compounds found in the source plant. Choose reputable suppliers with transparent sourcing practices.

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Biohacker Insights & Community Experiences

• Common Experiences: Due to its potency and toxicity concerns, Celastrol is not widely used in general biohacking communities. Anecdotal reports are scarce and often associated with experimental use or clinical research contexts.

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Frequently Asked Questions (FAQs)

• Is Celastrol safe for regular use?
  • Answer: The safety profile of purified Celastrol in humans is not well-established for regular use. It is a potent compound derived from a toxic plant, and its use should only occur under strict medical supervision due due to potential severe side effects.
• What is the best dosage of Celastrol?
  • Answer: There is no universally accepted or safe standard dosage for Celastrol in humans. Research uses very low amounts, and any dosage must be determined and monitored by a healthcare professional.

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Disclaimer

This guide is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any new supplement, especially if you have underlying health conditions or are taking medications.